Cerebral Autosomal Dominant Arteriopathy with Subcortical infarcts and Leukoencephalopathy (CADASIL)
https://openarchive.ki.se/xmlui/handle/10616/47639
A thesis to increase the understanding of the role of NOTCH3 dysregulation in vascular disease and in the developmental disorder IMF as well as provided important preclinical proof of concept data for novel therapeutic strategies aimed to interfere with the NOTCH3 misfolding and aggregation in CADASIL.