Our research summaries

Adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)/CSF1R related leukoencephalopathy https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.70192 Colony-stimulating factor 1 receptor–related disorder (CSF1R‑RD) is a rare and fast‑progressing brain disease caused by harmful changes in the CSF1R gene. People with this condition can develop a wide range of symptoms, including movement problems, cognitive decline, and behavioural changes. Symptoms usually begin in the […]

Adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)/CSF1R related leukoencephalopathy https://onlinelibrary.wiley.com/doi/10.1002/acn3.70250 Colony-stimulating factor 1 receptor–related disorder (CSF1R-RD) is a rare inherited neurodegenerative disease caused by changes in the CSF1R gene, which is essential for the health of microglia. People with CSF1R-RD typically develop progressive problems with thinking, behaviour, and movement in mid-adulthood, and the disease advances […]

Adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)/CSF1R related leukoencephalopathy https://www.science.org/doi/10.1126/science.adr1015 Link to download full text https://itbr.fudan.edu.cn/system/_content/download.jsp?urltype=news.DownloadAttachUrl&owner=1636857767&wbfileid=4CD58F979F5E0BB8AAB0F21C07C456FE Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a rare neurological disorder caused by mutations in the CSF1R gene, which impairs microglia, the brain’s resident immune cells. In this study, scientists discovered a new potential way of […]

Adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)/CSF1R related leukoencephalopathy https://investors.vigilneuro.com/news-releases/news-release-details/vigil-neuroscience-provides-update-iluzanebart-phase-2-ignite Vigil Neuroscience announced on 21st May that they will be acquired by Sanofi who have decided they will not be purchasing Iluzanebart (VGL101), Vigil’s monoclonal antibody being studied in a Phase 2 trial for adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). June 4th Vigil announced an update on […]

Adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)/CSF1R related leukoencephalopathy https://investors.vigilneuro.com/news-releases/news-release-details/vigil-neuroscience-reports-fourth-quarter-and-full-year-2024 Final analysis from IGNITE Phase 2 clinical trial for ALSP planned for second quarter of 2025. Vigil Neuroscience intend to pursue an accelerated approval pathway for iluzanebart in ALSP and expects to share an update on its progress when the final analysis is reported.

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)/CSF1R related leukoencephalopathy https://investors.vigilneuro.com/news-releases/news-release-details/vigil-neuroscience-highlights-2024-corporate-achievements-and Final analysis from the IGNITE Phase 2 clinical trial is planned for the second quarter of 2025. The Company will pursue an accelerated approval pathway for iluzanebart in ALSP and expects to share an update on its progress when the final analysis is reported.

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)/CSF1R related leukoencephalopathy https://www.nature.com/articles/s41598-024-84665-w Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a rare white matter disease leading to progressive neurological decline. Although the CSF1R gene is the primary causative gene for ALSP, it is unclear how many individuals clinically suspected to have ALSP present mutations in the CSF1R gene. This retrospective […]

Adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)/CSF1R related leukoencephalopathy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11398975 CSF1-Related Disorder (CSF1-RD)is a rare hereditary neurodegenerative disease related to colony-stimulating factor 1 (CSF1) gene mutations. As of February 2024, 199 pathogenic or likely pathogenic variants have been reported across several countries (3 newly reported countries in the present article), and most appear unique to […]

Adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)/CSF1R related leukoencephalopathy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11120026 This study investigates the role of chitinases (CHIT1 and CHI3L2) and neurofilament light chain (NfL) as prognostic and diagnostic biomarkers for adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a condition linked to mutations in the CSF1R gene. This study involved 63 participants across […]

Adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)/CSF1R related leukoencephalopathy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11261581 CSF1R-related disorder (CSF1R-RD) is a spectrum of white matter disorders genetically involving the CSF1R protein and clinically characterised by various cognitive impairments, neuropsychiatric changes and motor symptoms. Given the non-specific clinical presentations and lack of access to genetic testing, CSF1R-RD is thought to be frequently […]

Adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)/CSF1R related leukoencephalopathy https://investors.vigilneuro.com/news-releases/news-release-details/vigil-neuroscience-highlights-publication-alsp-genetic-mutation

Adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)/CSF1R related leukoencephalopathy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288773 This research article explores Brain Abnormalities, Neurodegeneration, and Dysosteosclerosis (BANDDOS), a rare genetic disorder caused by mutations in the CSF1R gene. BANDDOS is an autosomal-recessive condition, meaning both parents must carry the mutation for their child to be affected. The study highlights 19 cases, including […]