The different leukodystrophies
All of the conditions supported by Alex TLC are listed below, with information about the causes, symptoms and affected age range of each. These conditions have many common symptoms, grouped into 10 categories on our Symptoms and Treatment page. Each condition page will include links to the relevant categories of symptoms.
If you have been diagnosed with a leukodystrophy which does not have a name, or for which the genetic cause has not been established, please see our Unnamed and Undiagnosed Leukodystrophy page.
Condition list (A-Z)
Click on the links below to see more information about each condition. Many of these conditions have several names. If the condition you are looking for is not listed, it may be found under a name you are not familiar with. Use the search bar to help if needed.
- A
- AARS2-related leukodystrophy
- Addison’s Disease
- Adrenoleukodystrophy (ALD)
- Adrenomyeloneuropathy (AMN)
- Adult onset autosomal dominant leukodystrophy (ADLD)
- Aicardi-Goutieres Syndrome (AGS)
- Alexander Disease type 1
- Alexander Disease type 2
- C
- Canavan Disease (CD)
- Cathepsin-A Related Arteriopathy with Strokes And Leukoencephalopathy (CARASAL)
- Cerebral Autosomal Dominant Arteriopathy with Subcortical infarcts and Leukoencephalopathy (CADASIL)
- Cerebral Autosomal Recessive Arteriopathy with Subcortical infarcts and Leukoencephalopathy (CARASIL)
- Cerebrotendinous Xanthomatosis (CTX)
- CLCN2-related Leukoencephalopathy
- Coats plus Syndrome
- Cockayne Syndrome (CS)
- F
- Fucosidosis
- G
- Giant Axonal Neuropathy (GAN)
- GM1 gangliosidosis
- GM2 gangliosidosis
- H
- Hereditary diffuse leukoencephalopathy with spheroids (HDLS)
- HSPD1-related hypomyelination
- Hypomyelination with atrophy of the basal ganglia and cerebellum (H-ABC)
- Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL)
- Hypomyelination with congenital cataracts (HCC)
- K
- Krabbe Disease
- L
- L-2-hydroxyglutaric aciduria
- Leigh Syndrome
- Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL)
- Leukoencephalopathy with calcification and cysts (LCC)
- Leukoencephalopathy with thalamus and brainstem involvement and elevated lactate (LTBL)
- M
- Megalencephalic Leukodystrophy with subcortical cysts
- Metachromatic Leukodystrophy (MLD)
- 3-Methylglutaconic aciduria type 1 (MGCA1)
- Mucolipidosis type IV
- N
- Nasu-Hakola Disease (NHD)
- O
- Oculodentodigital Dysplasia with cerebral white matter abnormalities (ODD)
- P
- Pelizaeus-Merzbacher Disease (PMD)
- Pelizaeus-Merzbacher-like Disease (PMLD)
- Peroxisome Biogenesis Disorder (PBD)
- POLR1C related leukodystrophy
- POLR3 related leukodystrophy
- Polyglucosan Body Disease (PBD/APBD)
- R
- RARS related hypomyelination
- RNF216 Leukodystrophy
- S
- Sialic acid storage disorders:
- Sjogren Larsson Syndrome
- U
- Unnamed or Undiagnosed Leukodystrophy
- V
- Vanishing White Matter Disease (VWMD)
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